Anadrol (oxymetholone) is most likely second only to Dianabol (methandrostenolone) as a bodybuilding anabolic steroid. Additionally, it has had considerable medical importance particularly for treatment of anemia, and more recently to help maintain lean body mass in HIV-compromised patients. While many have the subjective opinion that Anadrol is a harsh drug in terms of side effects, medical findings and the findings of many athletes are quite different.
Stacking Anadrol with Other Steroids
An interesting further question concerns combination of Anadrol with other anabolic steroids. For exmaple, adding Anadrol to 50 mg/day of Dianabol gives little added benefit to a steroid cycle; in contrast, adding Anadrol to 50-100 mg/day trenbolone acetate or 60-80 mg/day Anavar (oxandrolone) gives dramatic improvement. In this its stacking behavior is similar to that of Dianabol, but not to that of trenbolone. Likely this is because unlike trenbolone, oxymetholone does not bind strongly to the androgen receptor, and most of its anabolic effect is likely not genomically mediated via the AR.
Anadrol Side Effects
With regard to harsh side effects sometimes perceived in bodybuilding, this principally or only occurs when estrogen levels are elevated. While oxymetholone does not itself aromatize and does not have estrogenic activity, it may be that it can interfere with estrogen metabolism. Whether that it is the cause of the problem or not, keeping estradiol levels under control keeps Anadrol similar in side effects to other oral anabolic steroids. Estradiol levels may be kept under control either by using an aromatase inhibitor such as letrozoleor Arimidex, or by limiting use of aromatizing steroids such as testosterone.
Generic name: Oxymetholone
Brand names: Anadrol, Anapolon, Anasteron, Dynasten, Hemogenin, Oxitosona 50, Plenastril, Roboral, Synasteron, Oxitoland.
Anadrol is an oral drug with a dosage of 50mg per tablet. It is the strongest oral on the market. It has both high androgenic and anabolic effects. Strength and weight gains are very significant. It is highly toxic to the liver. Anadrol also aromatizes fairly easily.
Many side effects are associated including acne, hair loss, abdominal pains, headaches, gynecomastia, hypertension, and heavy water retention. Loss of weight and strength usually occurs after the cycle. Anadrol also shuts down natural testosterone production. It is regarded by the bodybuilding community as the most effective oral steroid in building strength and size. Anadrol has many side effects however, which make it relatively dangerous to use when compared to other steroids.
Oxymetholone does not bind well to the androgen receptor, and most of the anabolism it provides is via non-androgenic receptor-mediated effects. It is therefore best stacked with an anabolic steroid like Deca Durabolin or Primobolan. The drug appears to give the same benefits as Dianabol. Unlike Dianabol, however, it seems that Oxymetholone is progestagenic. It has been observed to cause nipple soreness or to aggravate gynecomastia even in the presence of high dose antiestrogens, strongly suggesting that the effect is not estrogenic. That effect can be reduced by concurrent use of Stanozolol (Winstrol), which is anti-progestagenic. This progestagenic effect of oxymetholone is only a concern when using aromatizing steroids. With androgens such as Primobolan, Oxymetholone stacks very nicely and is a surprisingly friendly drug. In contrast, with testosterone it is a very harsh drug.
Because oxymetholone is 17-alkylated, it is stressful to the liver. It is better to limit use to no more than 6 weeks or preferably four weeks before taking a break of at least equal length. Many users feel that it is more effectively used in the beginning parts of the cycle, rather than in the last few weeks.
You might have read drug profiles and stories claiming that a weight gain of 40 pounds or more isn’t unusual with this drug. Since the start of this site, and as long back in time as this writer can remember, we haven’t talked to one person who’ve actually gained that much from this steroid alone. It seems like most of the drug profiles out there have been written by a third person who never tried the drugs himself, just heard stories about them. It is a good steroid, but only when it’s stacked with anabolic steroids.
For a first-timer, a daily dosage of 50-100 mg should be enough, divided into several doses per day. A more experienced user might need as much as 200 mg per day to get the effect he want, but the recommended dosage is in the range of 50-150 mg per day for no more than 6 weeks.